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Journal Editors Question Meridia
Editors of a top medical journal call Meridia "another flawed diet pill" and question whether it should stay on the market as a study shows it raises the risk of heart attack and stroke in people with heart problems.
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Major Leap Forward In TB Diagnostics
Scientists are reporting a major advance in diagnosing tuberculosis: A new test can reveal in less than two hours, with very high accuracy, whether someone has the disease and if it's resistant to the main drug for treating it.
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ND Supreme Court Weighs In On Precription Drug Law
Supporters of a voter initiative that could help bring cheaper prescription drugs to North Dakota are hoping a legal technicality won't keep them from getting the issue placed on the ballot.
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The Active Lives of Fat Cells
Scientists are reporting new evidence that fat tissue is far from being a dormant storage depot for surplus calories, it is an active organ that sends chemical signals to other parts of the body, perhaps increasing the risk of heart attacks, cancer, and other diseases.
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Botox Case Settled for $600M
Allergan Inc., the maker of wrinkle-smoothing Botox, says it will pay $600 million to settle a yearslong federal investigation into its marketing of the top-selling, botulin-based drug.
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More Headlines
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Cancer Research Moves Forward
 While the last few decades have been witness to progress in cancer research, many challenges remain. This edition of Vital Signs reviews new research and new tools that may change the way cancer is diagnosed and treated.
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Vital Signs: Battling Infectious Diseases
 Discovering effective tests for infectious disease in the US is one thing. Making them work in developing countries is another. Read about the latest developments in infectious disease research in Vital Signs, a digital magazine published by Drug Discovery & Development and Bioscience Technology.
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More Vital Signs
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Mammalian Cell Lines
Sigma Life Science, the biological products and research services business of Sigma-Aldrich Corporation, announced the global release of a pioneering range of engineered mammalian cell lines.
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Multipurpose Filters
 Meissner’s Steridyne 50 (PVDF) and Ultradyne 50 (PTFE) are multipurpose 50 mm filters for small volume venting, gas and solvent filtration. The filters are offered with stepped hose barb inlet/outlet connections.
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Flow Filtration System
Spectrum Laboratories, Inc. introduces the KrosFlo Research IIi Tangential Flow Filtration (TFF) System. When used with Spectrum’s hollow fiber filters, this compact, fully integrated system provides faster separation of proteins, cells, viruses, nanoparticles, and other macromolecules.
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Recirculating Chiller
Thermo Fisher Scientific Inc. announced the launch of its NESLAB ThermoFlex series of recirculating chillers. The ThermoFlex 24000 has a cooling capacity of 24,000 watts to meet the needs of customers who require a higher level of cooling performance.
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Thermoreversible Gel
The thermo-reversible mountant CyGEL, from Biostatus Ltd. in the UK, enables high resolution imaging of live 3D tumor spheroids cultured in low-adherence conditions and without fixation or cytospin centrifugation.
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More New Technologies
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Structured Drug Design
 Designing a new drug can be faster and more economical when researchers incorporate computational approaches. Software packages let scientists explore more structural options and even make predictions of the properties of new compounds.
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 Technology Advances
Adding Automation to Western Blotting
 When it comes to searching for specific proteins in a biological extract, many researchers still turn to the Western blot. Even after thirty years, this technique continues to be improved.
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To explore the three-dimensional structures of compounds, many researchers use the open-source PyMOL, which is maintained by Schrödinger.
Pharma companies migrate to high-content screening approaches to screen for kinase inhibitors.
RTS Life Science, a worldwide supplier of automated sample management and drug delivery testing systems, announces the availability of the 2010 Specification A3 SmaRTStore which offers exceptional storage density and improved future proofing.
New knockout rat models can be more effective predictors of pharmacokinetics.
While there are many challenges to running an efficient research laboratory, data management is one of the most critical issues facing scientists within drug discovery and development.
Concentration-gradient dynamic light scattering simplifies protein-protein interaction characterization.
The development of pharmaceuticals derived from cannabis took a major step forward in June when the UK’s Medicines and Healthcare Products Regulatory Agency approved the prescription use of Sativex to treat spasticity due to multiple sclerosis.
Regenerative medicine is a rapidly emerging field using stem cells to repair or restore function to tissues lost or damaged due to the effects of injury, disease, and aging.
In vivo CCD-based imaging instruments are ideal for both rapid screening and in-depth in vivo analysis for fluorescent protein expressed in plants and animals.
Reliable models of bone metastasis are needed to develop new drugs for preventing or treating metastatic bone tumors and the subsequent bone erosion.
Preclinical animal models provide researchers with valuable insight into the efficacy and mechanism of action of a therapy in a living animal rather than in isolated cultured cells.
Accurately predicted retention times are useful for everything from the selection of generic methods and development of screening methods to the identification of metabolites and impurities in drug discovery studies.
In the United States, over eight million adults over age 50 suffer from peripheral arterial disease (PAD), a serious condition that commonly results from progressive narrowing of arteries in the lower extremities due to atherosclerosis.
A new paradigm shift has the ability to transform outsourced clinical research and give rise to a new kind of contract research organization, the digital CRO.
