Shimadzu Scientific Instruments introduces the Prominence nano, a high-performance liquid chromatograph that supports high-precision gradient analysis by providing advanced flow-rate precision in the nano flow-rate range. Prominence nano delivers exact flow rates via two LC-20ADnano pumps that are independently controlled by feedback from integrated high-precision nano flow sensors. The instrument’s Reflux Flow Control System (patent pending) stabilizes solvent delivery and ensures low solvent consumption with no disposal of split flow, minimizing environmental impact.

Prominence nano is configured with Shimadzu’s FCV nano switching valve to optimize bio sample analysis in the nL/min level for trap injection and 2D LC applications. With the low dead volume FCV nano, the volume between ports is as low as 25 nL, so there is virtually no peak broadening in the nano flow-rate range. The valve also minimizes clogging caused by friction and reduces adsorption of analytical samples relative to typical flow-switching valves.

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This article was published in Drug Discovery & Development magazine: Vol. 11, No. 7, July, 2008, pp. 19.