Waters Corporation unveiled several new mass spectrometry innovations at the 56th American Society for Mass Spectrometry Conference including the Waters XevoTM TQ MS System, an advanced tandem quadrupole mass spectrometer that allows scientists with varying levels of mass spectrometry (MS) expertise to quickly produce the highest quality data with confidence.
In addition, the company previewed the TRIZAIC UPLC System with nanoTile technology, a new UltraPerformance LC separations platform for both large- and small-molecule applications that will deliver information-rich, high-sensitivity analyses when coupled to Waters SYNAPT High Definition MS (HDMS) and SYNAPT MS Systems. Other products announced include the VERIFYE High Definition Proteomics System, the nanoACQUITY UPLC System with 2D Technology, and the Atmospheric Solids Analysis Probe (ASAP).
Accessible High-End MS Performance
The Xevo TQ MS System is an advanced tandem quadrupole mass spectrometer that uses innovative IntelliStart and ScanWave technologies to deliver versatility and advanced quantitative capability to a broader range of scientists. IntelliStart is new technology that simplifies instrument setup and time-intensive troubleshooting, according to Waters. It automatically ensures the system is ready for use by performing mass calibration, setting MS resolution, generating compound-specific MS methods (SIR or MRM) and optimizing API source conditions for specific analytical conditions plus much more.
The Xevo TQ MS System operating under MassLynx Software is equipped with a collision cell that can be operated in conventional T-Wave1-enabled mode or in a new ScanWave-enabled mode. The ScanWave is an application of T-Wave collision cell technology that improves duty cycle and significantly enhances the full scan capability for complex analyses. This allows scientists to more easily confirm the identities and structures of targeted analytes.
Separations Platform for Proteomics Research
The TRIZAIC UPLC System with nanoTile Technology is designed to deliver exceptional sensitivity for limited-sample, direct-flow, nanoscale protein separations, according to Waters. For use with Waters SYNAPT HDMS and SYNAPT MS Systems, it combines novel microfluidic separation technology with Waters sub-two-micron column chemistries, unique solvent delivery and comprehensive data management for both large- and small-molecule applications.
From Discovery to Hypothesis-Driven Proteomics
Waters augmented its High Definition Proteomic strategy with the introduction of the new VERIFYE System solution for biomarker verification. VERIFYE delivers the fastest transition from global-discovery to targeted proteomics by expertly selecting proteotypic peptides for quantitative protein assays along with optimum Multiple Reaction Monitoring (MRM) parameters. It uniquely develops targeted UPLC/MS/MS methods by interrogating archived global-discovery data in contrast to commonly used in silico projections of proteotypic peptide suitability.
The VERIFYE system solution is optimized for use with Waters TRIZAIC UPLC and Xevo TQ MS technologies.
LC Separations of Proteins
Waters nanoACQUITY UPLC System with 2D Technology expands the use of sub-2-micron particles to achieve high-peak-capacity separations. Waters 2D approach employs reversed-phase chromatography at pH 10 in the first dimension, followed by reversed-phase chromatography at pH 2. By exploiting the wide-ranging ionic and hydrophobic structure of peptides, this new method offers better protein identifications, quantification, and sequence coverage than conventional one-dimensional or two-dimensional technology employing strong cation exchange chromatography in the first dimension and reversed-phase chromatography in the second dimension.
Direct Ionization Interface for Mass Spectrometry
The Atmospheric Solids Analysis Probe (ASAP) allows direct ionization of samples using the Z-Spray atmospheric pressure ionization (API) source of a Waters mass spectrometer. The ASAP probe permits fast analysis of solid, liquid, tissue, or material such as polymer samples, by vaporizing the sample with the hot desolvation gas from the API probe.
Waters and Rosetta Biosoftware Showcase Results of Collaboration
Rosetta Biosoftware in collaboration with Waters has enabled its Rosetta Elucidator system to mine Waters UPLC/MSE, high-bandwidth, proteomics discovery data and integrate the Waters IdentityE search engine for secure protein identifications. The solution is already in use by the companies' mutual customers.
Advancements in SYNAPT Technology
Waters announced advancements to its High Definition Imaging (HDI) MALDI System, based on the dual-ionization MALDI SYNAPT HDMS System. Mobility Data Directed AnalysisTM (Mobility DDATM) provides enhanced MS/MS analysis from limited sample amounts. Mobility DDA leverages the system’s high efficiency ion mobility capabilities to provide low level detection limits and higher-quality MS/MS spectra to aid automated, unambiguous identification of proteins in the femtomolar and attomolar range.
The SYNAPT MS system replaces the Waters Q-TofTM Premier product and which is readily upgradeable to perform High Definition MS experiments.
Instrument Control Software
With the release of ACQUITY UPLC v 1.31 Instrument Control Software, Waters now offers greater operational integration and connectivity between Waters ACQUITY UPLC System and ABI/MDS Analytical Technologies mass spectrometers on Analyst and Analyst QS mass spectrometry software.
Release Date: June 2, 2008
Source: Waters Corporation
